High risk human papillomavirus and Epstein Barr virus in human breast milk.
High risk human papillomavirus and Epstein Barr virus in human breast milk.
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DOI：
10.1186/1756-0500-5-477
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发表时间：
2012-09-01
影响因子：
1.8
通讯作者：
Lawson, James S
中科院分区：
文献类型：
--
作者：
Glenn, Wendy K;Whitaker, Noel J;Lawson, James S
背景：人类乳汁中已发现多种病毒，包括人类免疫缺陷病毒、EB病毒（EBV）和小鼠乳腺肿瘤病毒。已在乳腺癌中鉴定出高风险人乳头瘤病毒 (HPV) 序列。本研究的目的是确定正常哺乳期妇女的母乳中是否存在病毒序列。调查结果：使用标准（液体）和原位聚合酶链反应 (PCR) 技术来鉴定无乳腺癌病史的正常哺乳期澳大利亚妇女的母乳样本中的 HPV 和 EBV。在正常哺乳期妇女的 40 份乳汁样本中，有 6 份 (15%) 被鉴定出高危人乳头瘤病毒 - 对 4 个样本的测序显示，3 个样本为 HPV 16，1 个样本为 HPV 16。 HPV 18。在 14 个样本 (33%) 中发现了 Epstein Barr 病毒。结论：母乳中存在高危 HPV 和 EBV，表明这些病毒可能通过乳汁传播。然而，鉴于年轻人中病毒相关恶性肿瘤的罕见性，这种传播有可能但不太可能与乳腺癌或其他癌症有关。
BACKGROUND: Multiple viruses, including human immunodeficiency virus, Epstein Barr virus (EBV) and mouse mammary tumour virus have been identified in human milk. High risk human papillomavirus (HPV) sequences have been identified in breast cancer. The aim of this study is to determine if viral sequences are present in human milk from normal lactating women.FINDINGS: Standard (liquid) and in situ polymerase chain reaction (PCR) techniques were used to identify HPV and EBV in human milk samples from normal lactating Australian women who had no history of breast cancer.High risk human papillomavirus was identified in milk samples of 6 of 40 (15%) from normal lactating women - sequencing on four samples showed three were HPV 16 and one was HPV 18. Epstein Barr virus was identified in fourteen samples (33%).CONCLUSION: The presence of high risk HPV and EBV in human milk suggests the possibility of milk transmission of these viruses. However, given the rarity of viral associated malignancies in young people, it is possible but unlikely, that such transmission is associated with breast or other cancers.