Targeted photostimulation uncovers circuit motifs supporting short-term memory
Targeted photostimulation uncovers circuit motifs supporting short-term memory
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DOI：
10.1038/s41593-020-00776-3
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发表时间：
2021-01-25
影响因子：
25
通讯作者：
Druckmann, Shaul
中科院分区：
文献类型：
--
作者：
Daie, Kayvon;Svoboda, Karel;Druckmann, Shaul
双光子光刺激和皮层短期记忆电路成像揭示了能够独立维持记忆的插入模块。这些模块由具有相似任务相关调优的神经元之间的连通性来定义。短期记忆与持续的神经活动有关，这种活动是由神经元之间的正反馈维持的。为了探索产生记忆相关持续性活动的神经回路基元，我们测量了执行记忆引导反应任务的小鼠的功能特征运动皮层神经元之间的耦合。定向双光子光刺激小(
Two-photon photostimulation and imaging of a cortical short-term memory circuit reveal intercalated modules that can independently maintain memory. The modules are defined by connectivity between neurons with similar task-related tuning.Short-term memory is associated with persistent neural activity that is maintained by positive feedback between neurons. To explore the neural circuit motifs that produce memory-related persistent activity, we measured coupling between functionally characterized motor cortex neurons in mice performing a memory-guided response task. Targeted two-photon photostimulation of small (