Quadruple helix formation of a photoresponsive peptide amphiphile and its light-triggered dissociation into single fibers
Quadruple helix formation of a photoresponsive peptide amphiphile and its light-triggered dissociation into single fibers
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DOI：
10.1021/ja711213s
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发表时间：
2008-03-12
影响因子：
15
通讯作者：
Stupp, Samuel I.
中科院分区：
文献类型：
--
作者：
Muraoka, Takahiro;Cui, Honggang;Stupp, Samuel I.
利用一种在烷基链和肽段之间有一个大的光敏性2-硝基苯基的肽两亲体，我们证明了四螺旋纤维的形成及其在光响应下解离成单纤维。把大的基团放在靠近纤维核心的地方被认为会引起分子排列的扭曲，这反过来会导致四重螺旋。光照射使大团分裂，使螺旋变成单个的原纤维。
Using a peptide amphiphile having a bulky photolabile 2-nitrobenzyl group between the alkyl chain and the peptide segment, we demonstrated quadruple helical fiber formation and its dissociation into single fibrils in response to light. Putting the bulky group close to the core of a fibril is thought to induce a distortion of the alignment of molecules, which can in turn lead to quadruple helices. Photoirradiation to cleave the bulky group transforms the helices into single fibrils.