Systemic morphine in the prevention of allodynia in the rat spinal nerve ligation model of neuropathic pain
Systemic morphine in the prevention of allodynia in the rat spinal nerve ligation model of neuropathic pain
复制标题
DOI：
10.1016/s1090-3801(98)90044-1
复制
发表时间：
1998-01-01
影响因子：
3.6
通讯作者：
Kalso, E
中科院分区：
文献类型：
--
作者：
Kontinen, VK;Paananen, S;Kalso, E
周围神经损伤可能导致神经性疼痛，这种疼痛被认为对阿片类药物无反应。在神经性疼痛的动物模型中，先前有阿片类药物作用增强和减弱的数据，但关于阿片类药物治疗对神经病变症状发展的长期作用的信息有限。在单侧周围神经病变大鼠中研究了在损伤前注射吗啡或在损伤后长期注射吗啡预防神经病变体征发展的可能性，这些大鼠由于L5和L 6脊神经的紧密结扎而发生了机械性和冷异常性疼痛，但没有热痛觉过敏。无论是在神经损伤前单次皮下注射吗啡（10 mg/kg），还是在手术后立即开始使用缓释药丸（1、2或5个药丸含有75 mg吗啡，导致总剂量为75、150或375 mg）进行长期给药，都不能预防机械性或冷异常性疼痛的发生。在所有大鼠中均未观察到自残、痛苦体征、社会行为改变或吗啡戒断。神经性疼痛样症状没有被任何研究的治疗所减弱的事实表明，无论是术前用药还是术后全身吗啡疼痛管理都不能有效预防术后神经性疼痛。
Peripheral nerve injury may lead to neuropathic pain that has been considered unresponsive to opioids. In animal models of neuropathic pain, there are previous data of both increased and decreased effect of opioids, but only limited information of the long-term effects of opioid treatment on the development of the symptoms of neuropathy. The possibility of preventing the development of signs of neuropathy with either a single preinjury injection or chronic postinjury administration of morphine was studied in rats with unilateral peripheral neuropathy due to tight ligation of the L5 and L6 spinal nerves.These rats developed both mechanical and cold allodynia, but no thermal hyperalgesia. Neither subcutaneous morphine given as single injection (10 mg/kg) before the nerve injury nor chronic administration starting immediately after surgery using slow-release pellets (one, two or five pellets containing 75 mg of morphine, resulting in a total dose of 75, 150 or 375 mg) prevented the development of either mechanical or cold allodynia. No autotomy, signs of distress, altered social behaviour or morphine withdrawal was seen in any of the rats. The fact that neuropathic pain-like symptoms were not attenuated by any of the treatments studied could indicate that neither premedication nor postoperative pain management with systemic morphine is effective in preventing postoperative neuropathic pain.