Association of Adenoid Surface Biofilm Formation and Chronic Otitis Media With Effusion
Association of Adenoid Surface Biofilm Formation and Chronic Otitis Media With Effusion
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DOI：
10.1001/archoto.2010.70
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发表时间：
2010-06-01
影响因子：
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通讯作者：
Korkmaz, Hakan
中科院分区：
文献类型：
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作者：
Saylam, Gueleser;Tatar, Emel Cadalli;Korkmaz, Hakan
目的：研究腺样体切除术患儿腺样体表面细菌生物膜的形成，并揭示这种形成是否与慢性渗出性中耳炎（COME）有关。设计：前瞻性，单盲研究，扫描电子显微镜检查。设置：土耳其安卡拉Yildirim Beyazit研究和教育医院。患者：从2007年6月1日至12月31日，34名4至15岁（平均年龄7.76岁）的儿童接受了腺样体切除术，分为2组。第一组（17名儿童）进行了腺样体切除术单独，而第二组（17名儿童）进行了腺样体切除术结合通气管插入COME.Main结果测量：扫描电子显微镜进行观察腺样体组织表面的生物膜形成。生物膜形成根据延伸分级。腺样体大小，年龄，性别和COME症状的持续时间的作用进行了evaluated.Results：生物膜形成检测所有样本。从COME患者中取出的腺样体比其他组有更高级别的生物膜形成（P = .001）。结论：儿童腺样体表面生物膜的形成可能与COME的发病机制有关。
Objectives: To investigate bacterial biofilm formation on the adenoid surface of pediatric patients undergoing adenoidectomy and to reveal whether this formation is associated with chronic otitis media with effusion (COME).Design: Prospective, single-blinded study with scanning electron microscopy.Setting: Diskapi Yildirim Beyazit Research and Educational Hospital, Ankara, Turkey.Patients: Thirty-four children between 4 and 15 years of age (mean age, 7.76 years) who had undergone adenoidectomy from June 1 through December 31, 2007, were divided into 2 groups. The first group (17 children) had undergone adenoidectomy alone, whereas the second group (17 children) had undergone adenoidectomy combined with ventilation tube insertion for COME.Main Outcome Measures: Scanning electron microscopy was performed to observe biofilm formation on the surface of adenoid tissues. The biofilm formation was graded according to extension. The roles of adenoid size, age, sex, and duration of COME symptoms were evaluated.Results: Biofilm formation was detected on all samples. Adenoids removed from patients with COME had higher-grade biofilm formation than the other group (P = .001). No correlation was found between adenoid size and biofilm formation.Conclusion: In pediatric patients, adenoid surface biofilm formation may be associated with COME etiopathogenesis.