Diet quality and markers of endothelial function: The CARDIA study
Diet quality and markers of endothelial function: The CARDIA study
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DOI：
10.1016/j.numecd.2013.12.010
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发表时间：
2014-06-01
影响因子：
3.9
通讯作者：
Jacobs, D. R., Jr.
中科院分区：
文献类型：
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作者：
Sijtsma, F. P. C.;Meyer, K. A.;Jacobs, D. R., Jr.
背景和目的：膳食模式与细胞粘附分子（CAM）有着密切的关系。我们研究了前瞻性协会的三种饮食模式与CAMS.Methods和结果：在冠状动脉风险发展的年轻人（CARDIA）的研究，饮食进行了评估，在0年（1985-86年）和7（1992-93年）检查。在第7年和第15年（2000-01年）检测了四种循环CAM（E-选择素、P-选择素、可溶性细胞间粘附分子1（sICAM-1）和血管细胞粘附分子（VCAM））。我们创建了一个指数得分“先验饮食质量得分”，并使用主成分分析（PCA）得出饮食模式。多变量线性回归模型从平均（0/7年）饮食模式预测15年CAM。A Priori饮食质量评分根据假设的健康影响对46种食物组进行了有益、中性或不利的评级。我们得出了两种PCA饮食模式：“水果和蔬菜（FV）”（水果，蔬菜和全谷物的高摄入量）和“肉”（红肉，精制谷物和黄油的高摄入量）。所有膳食模式均与E-选择素和sICAM-1相关。P-选择素与FV饮食模式无关。VCAM仅与A Priori饮食质量评分相关。最强的关联是肉类饮食模式与E-选择素（效应量为SD的28%（+3.9/13.7 ng/mL））和P-选择素（效应量为SD的37%（+4.1/11.2 ng/mL））和A Priori饮食质量评分与sICAM-1（SD的效应量为34%（-15.1/44.7 ng/mL））和VCAM（SD的效应量为26%（-45.1/170.3 ng/mL））。(C)2014年爱思唯尔B。版权所有© 2016
Background and aim: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs.Methods and results: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score "A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7 ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2 ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7 ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3 ng/mL)).Conclusion: This prospective analysis suggests that dietary patterns are associated with CAMs. (C) 2014 Elsevier B. V. All rights reserved.