Expression of K+ channels in normal and cancerous human breast
Expression of K+ channels in normal and cancerous human breast
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DOI：
10.14670/hh-23.965
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发表时间：
2008-08-01
影响因子：
2
通讯作者：
Ouadid-Ahidouch, Halima
中科院分区：
文献类型：
--
作者：
Brevet, Marie;Ahidouch, Ahmed;Ouadid-Ahidouch, Halima
钾离子通道（K+ channels）参与细胞增殖和凋亡的调节，并参与肿瘤的发生和恶性生长。（G-蛋白抑制整流钾通道1），Ca 2+激活钾通道本研究检测了正常乳腺组织和乳腺癌组织中钾离子通道（K-Ca 1.1）、电压激活钾离子通道（K-V 1.1和K-V 1.3）和抗凋亡蛋白Bcl 2的表达，并与临床病理资料进行了比较。GIRK 1在癌组织中过表达。相反，KV 1.1和K-V 1.3在癌组织中表达较少。Bcl-2在两种组织中的表达相似。临床病理资料显示，K（Ca）1. 1通道与雌激素受体（ER）表达相关，GIRK 1在乳腺癌中过表达，提示其参与乳腺癌的增殖和肿瘤发生，可能是一个潜在的药物靶点。K（Ca）1.1通道与ER的相关性提示该通道参与细胞增殖。K-V1. 1和K-V1. 3两个通道表达的缺失可能与它们在凋亡中的作用相对应。
Potassium (K+) channels contribute to the regulation of cell proliferation and apoptosis and are also involved in tumor generation and malignant growth.Using immunohistochemical analysis, we investigated the expression of four K+ channels GIRK1 (G- Protein Inwardly Rectifying Potassium Channel 1), Ca2+- activated K channel (K-Ca 1.1), voltage activated K+ channels (K-V 1.1 and K-V 1.3) and of the anti-apoptotic protein Bcl2 in normal and cancerous breast tissues and compared their expression with clinicopathological data. GIRK1 was overexpressed in carcinomatous tissues. In contrast, KV 1.1 and K-V 1.3 were less expressed in cancerous tissue. The expression of Bcl-2 was similar in both tissues. As to the clinicopathological data, a correlation between K(Ca)1.1 channel and estrogen receptor (ER) expression was observed.GIRK1 was overexpressed in breast carcinoma suggesting its involvement in proliferation and oncogenesis and its possible use as a putative pharmaceutigal target. The correlation between K(Ca)1.1 channel and ER suggests the involvement of this channel in proliferation. The loss of expression of the two channels K-V 1.1 and K-V 1.3 may correspond to their role in apoptosis.