Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores
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DOI：
10.1007/978-3-030-12457-1_15
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发表时间：
2020-01-01
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影响因子：
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通讯作者：
Chuang, Kai-Ting
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文献类型：
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作者：
Galione, Antony;Chuang, Kai-Ting
Ca2+信号可能是最常见的细胞内信号传导细胞事件，控制着几乎所有细胞的广泛反应。许多细胞刺激通常作用于细胞表面受体，通过动员细胞内储存的Ca2+来唤起Ca2+信号。肌醇三磷酸（IP3）是第一个通过激活IP3门控的Ca2+释放通道（IP3受体），将质膜上的事件联系起来，从内质网（ER）释放Ca2+的信使。随后，另外两个Ca2+动员信使被发现，cADPR和NAADP。两者都是吡啶核苷酸的代谢物，可以由同一类酶产生，adp -核糖基环化酶，如CD38。cADPR通过激活ryanodine受体（RyRs）从内质网中动员Ca2+， NAADP通过激活两个孔通道（TPCs）的机制从酸性储存中释放Ca2+。此外，其他的吡啶核苷酸也作为细胞内信使出现。adp -核糖和2'-脱氧- adpr都激活在质膜和溶酶体中表达的TRPM2通道。
Ca2+ signals are probably the most common intracellular signaling cellular events, controlling an extensive range of responses in virtually all cells. Many cellular stimuli, often acting at cell surface receptors, evoke Ca2+ signals by mobilizing Ca2+ from intracellular stores. Inositol trisphosphate (IP3) was the first messenger shown to link events at the plasma membrane to release Ca2+ from the endoplasmic reticulum (ER), through the activation of IP3-gated Ca2+ release channels (IP3 receptors). Subsequently, two additional Ca2+ mobilizing messengers were discovered, cADPR and NAADP. Both are metabolites of pyridine nucleotides, and may be produced by the same class of enzymes, ADP-ribosyl cyclases, such as CD38. Whilst cADPR mobilizes Ca2+ from the ER by activation of ryanodine receptors (RyRs), NAADP releases Ca2+ from acidic stores by a mechanism involving the activation of two pore channels (TPCs). In addition, other pyridine nucleotides have emerged as intracellular messengers. ADP-ribose and 2'-deoxy-ADPR both activate TRPM2 channels which are expressed at the plasma membrane and in lysosomes.