Impact of high-throughput screening in biomedical research
Impact of high-throughput screening in biomedical research
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DOI：
10.1038/nrd3368
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发表时间：
2011-03-01
影响因子：
120.1
通讯作者：
Sittampalam, G. Sitta
中科院分区：
文献类型：
--
作者：
Macarron, Ricardo;Banks, Martyn N.;Sittampalam, G. Sitta
高通量筛选（HTS）已被假定在几个季度是在制药行业的生产力下降的一个促成因素。此外，它被指责为扼杀了药物发现所需的创造力。在这篇文章中，我们的目标是消除这些神话，并提出使用HTS作为一个成熟的科学工具包的一部分，更广泛地使用它是发现新的化学型必不可少的情况。
High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.