Gene transposition as a cause of hybrid sterility in Drosophila
Gene transposition as a cause of hybrid sterility in Drosophila
复制标题
DOI：
10.1126/science.1128721
复制
发表时间：
2006-09-08
期刊：
影响因子：
56.9
通讯作者：
Orr, H. Allen
中科院分区：
文献类型：
--
作者：
Masly, John P.;Jones, Corbin D.;Orr, H. Allen
我们描述生殖隔离所造成的基因换位。在某些果蝇中- D。在simulans杂种中，杂种雄性不育是由缺乏雄性育性所必需的单拷贝基因JYAlpha引起的。该基因位于D. melanogaster的第3条染色体上。simulans。基因组和分子生物学分析表明，JYAlpha在果蝇进化过程中发生了第三条染色体的易位。simulans血统由于这种转座，一部分杂交种完全缺乏JYAlpha并且不育，代表没有序列进化的生殖隔离。
We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster - D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.