Cystatins in health and disease.
Cystatins in health and disease.
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DOI：
10.1515/bchm3.1996.377.2.71
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发表时间：
1996-02
期刊：
影响因子：
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通讯作者：
Y. Henskens;E. Veerman;A. N. Nieuw Amerongen
中科院分区：
文献类型：
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作者：
Y. Henskens;E. Veerman;A. N. Nieuw Amerongen
蛋白水解酶在植物、细菌、病毒、原生动物和哺乳动物中具有多种生理功能。它们在食物消化、补体激活或血液凝固等过程中发挥作用。蛋白水解酶的作用受蛋白酶抑制剂的生物学控制，这些天然抑制剂在病理过程中的生理意义越来越受到关注。这一日益增长的兴趣的原因是，不受控制的蛋白质水解可导致不可逆的损伤，如慢性炎症或肿瘤转移。本文综述了半胱氨酸蛋白酶的天然和特异性抑制剂半胱氨酸抑素在病理过程中的可能作用。
Proteolytic enzymes have many physiological functions in plants, bacteria, viruses, protozoa and mammals. They play a role in processes such as food digestion, complement activation or blood coagulation. The action of proteolytic enzymes is biologically controlled by proteinase inhibitors and increasing attention is being paid to the physiological significance of these natural inhibitors in pathological processes. The reason for this growing interest is that uncontrolled proteolysis can lead to irreversible damage e.g. in chronic inflammation or tumor metastasis. This review focusses on the possible role of the cystatins, natural and specific inhibitors of the cysteine proteinases, in pathological processes.