Detection of Mayaro virus infections during a dengue outbreak in Mato Grosso, Brazil
Detection of Mayaro virus infections during a dengue outbreak in Mato Grosso, Brazil
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DOI：
10.1016/j.actatropica.2015.03.020
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发表时间：
2015-07-01
期刊：
影响因子：
2.7
通讯作者：
de Morais Bronzoni, Roberta Vieira
中科院分区：
文献类型：
--
作者：
da Silva Pessoa Vieira, Carla Julia;Ferreira da Silva, David Jose;de Morais Bronzoni, Roberta Vieira
虫媒病毒是世界范围内人类发热性疾病的常见病原体。在登革热流行地区，其他虫媒病毒引起的疾病仅根据临床流行病学数据被误诊为登革热。在这项研究中，我们调查了巴西的虫媒病毒在200例急性发热性疾病，在锡诺普，MT，巴西登革热爆发的患者血清中的存在。结果显示，38份样本对登革病毒1型呈阳性反应，2份样本对登革病毒4型呈阳性反应，6份样本对马亚罗病毒呈阳性反应。这些结果表明，除登革病毒以外的虫媒病毒正在锡诺普及其周边地区传播，这些病毒尚未得到诊断。此外，分子和进化分析表明，两个MAYV基因型是共同循环在巴西马托格罗索州。因此，必须实施强有力的监测计划，以评估和监测非登革虫媒病毒在急性发热性疾病病因学中的分布和真正重要性。(C)2015爱思唯尔B.V.保留所有权利。
Arboviruses are common agents of human febrile illness worldwide. In dengue-endemic areas illness due to other arboviruses have been misdiagnosed as dengue based only on clinical-epidemiological data. In this study we investigated the presence of Brazilian arboviruses in sera of 200 patients presenting acute febrile illness, during a dengue outbreak in Sinop, MT, Brazil. The results showed that 38 samples were positive to Dengue virus (DENV) type 1, two samples to DENV type 4, and six to Mayaro virus. These results indicate that arboviruses others than DENV are circulating in Sinop and the surrounding region, which are going undiagnosed. In addition, molecular and evolutionary analyses indicate that two MAYV genotypes are co-circulating in Mato Grosso, Brazil. Thus, a strong surveillance program must be implemented to evaluate and monitor the distribution and the true importance of non-dengue arboviruses in the etiology of acute febrile illnesses. (C) 2015 Elsevier B.V. All rights reserved.