Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action
Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action
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DOI：
10.1016/0014-5793(93)81809-e
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发表时间：
1993-07
期刊：
影响因子：
3.5
通讯作者：
H. Wiseman
中科院分区：
文献类型：
--
作者：
H. Wiseman
维生素 D 是一种膜抗氧化剂：因此维生素 D3（胆钙化醇）及其活性代谢物 1,25-二羟基胆钙化醇以及维生素 D2（麦角钙化醇）和 7-脱氢胆固醇（维生素 D3 前体）均可抑制铁依赖性脂质体脂质过氧化。胆钙化醇、1,25-二羟基胆钙化醇和麦角钙化醇作为脂质过氧化抑制剂的效果相似，但不如 7-脱氢胆固醇有效；这是比胆固醇更好的脂质过氧化抑制剂，但不是麦角甾醇。这些维生素 D 化合物的抗氧化能力的结构基础是根据它们与胆固醇和麦角甾醇的分子关系来考虑的。此外，还将维生素 D 的抗氧化能力与抗癌药物他莫昔芬及其 4-羟基代谢物（胆固醇的结构模拟物）的抗氧化能力进行了比较，并讨论了该维生素的抗癌作用。
Vitamin D is a membrane antioxidant: thus Vitamin D3(cholecalciferol) and its active metabolite 1,25‐dihydroxycholecalciferol and also Vitamin D2(ergocalciferol) and 7‐dehydrocholesterol (pro‐Vitamin D3) all inhibited iron‐dependent liposomal lipid peroxidation. Cholecalciferol, 1,25‐dihydroxycholecalciferol and ergocalciferol were all of similar effectiveness as inhibitors of lipid peroxidation but were less effective than 7‐dehydrocholesterol; this was a better inhibitor of lipid peroxidation than cholesterol, though not ergosterol. The structural basis for the antioxidant ability of these Vitamin D compounds is considered in terms of their molecular relationship to cholesterol and ergosterol. Furthermore, the antioxidant ability of Vitamin D is compared to that of the anticancer drug tamoxifen and its 4‐hydroxy metabolite (structural mimics of cholesterol) and discussed in relation to the anticancer action of this vitamin.