Predictors of the timing of natural menopause in the multiethnic cohort study
Predictors of the timing of natural menopause in the multiethnic cohort study
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DOI：
10.1093/aje/kwn046
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发表时间：
2008-06-01
影响因子：
5
通讯作者：
Pike, Malcolm C.
中科院分区：
文献类型：
--
作者：
Henderson, Katherine DeLellis;Bernstein, Leslie;Pike, Malcolm C.
自然绝经的时间对几个健康终点有影响;特别是，它是乳腺癌的风险因素。作者调查了多种族队列研究中5个种族/民族的95，704名平均年龄为59.7岁（第10 - 90百分位数范围，47.0-71.0）的女性自然绝经时间的影响因素，包括非拉丁裔白人，日裔美国人，非洲裔美国人，夏威夷土著人和拉丁裔。作者调查了种族/民族和几种生活方式和生殖特征是否与自然绝经的时间有关。种族/民族是自然绝经时间的重要独立预测因素。其他因素，包括吸烟、初潮年龄、产次和体重指数，没有显著改变种族/民族特异性风险比。相对于非拉丁裔白人，拉丁裔的自然绝经期较早（美国出生的拉丁裔：风险比（HR）= 1.10，95%置信区间（CI）：1.07，1.14;非美国出生的拉丁裔：HR = 1.25，95% CI：1.21，1.30），日裔美国人较晚（HR = 0.93，95% CI：0.90，0.95）。这些结果支持了自然绝经的时间是由遗传，生殖和生活方式因素共同驱动的假设。
The timing of natural menopause has implications for several health endpoints; in particular, it is a risk factor for breast cancer. The authors investigated factors influencing the timing of natural menopause among 95,704 women with a mean age of 59.7 years (10th-90th percentile range, 47.0-71.0) in five racial/ethnic groups in the Multiethnic Cohort Study, including non-Latina Whites, Japanese Americans, African Americans, Native Hawai'ians, and Latinas. The authors investigated whether race/ethnicity and several lifestyle and reproductive characteristics were associated with the timing of natural menopause. Race/ethnicity was a significant independent predictor of the timing of natural menopause. Other factors, including smoking, age at menarche, parity, and body mass index, did not significantly alter the race/ethnicity-specific hazard ratios. Relative to non-Latina Whites, natural menopause occurred earlier among Latinas (US-born Latinas: hazard ratio (HR) = 1.10, 95% confidence interval (CI): 1.07, 1.14; non-US-born Latinas: HR = 1.25, 95% CI: 1.21, 1.30) and later among Japanese Americans (HR = 0.93, 95% CI: 0.90, 0.95). These results support the hypothesis that the timing of natural menopause is driven by a combination of genetic, reproductive, and lifestyle factors.