Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions
Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions
复制标题
DOI：
10.1021/ol5017965
复制
发表时间：
2014-08-01
期刊：
影响因子：
5.2
通讯作者：
Helquist, Paul
中科院分区：
文献类型：
--
作者：
Grigalunas, Michael;Ankner, Tobias;Helquist, Paul
一个温和的，催化的，分子间烯基化酮烯醇化物的协议已开发使用Pd/Q-Phos催化剂。使用稍微过量的LiHMDS和低至0 ℃的温度实现了各种酮与烯基溴的有效分子间偶联。
A protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates has been developed using a Pd/Q-Phos catalyst. Efficient intermolecular coupling of a variety of ketones with alkenyl bromides was achieved with a slight excess of LiHMDS and temperatures down to 0 degrees C.