The universal protein resource (UniProt)
The universal protein resource (UniProt)
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DOI：
10.1093/nar/gkl929
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发表时间：
2007-01-01
影响因子：
14.9
通讯作者：
Zhang, Jian
中科院分区：
文献类型：
--
作者：
Bairoch, Amos;Bougueleret, Lydie;Zhang, Jian
存储和互连所有有关蛋白质的所有可用信息的能力对于现代生物学研究至关重要。因此，通用蛋白质资源（UNIPROT）通过在蛋白质序列和功能注释上提供稳定，全面，自由访问的中心资源，从而起着越来越重要的作用。 Uniprot由Uniprot联盟生产，该联盟由欧洲生物信息学研究所（EBI），蛋白质信息资源（PIR）和瑞士生物信息学研究所（SIB）于2002年成立。核心活动包括通过计算分析辅助的蛋白质序列的手动策划，序列归档，用户友好的Uniprot网站的开发以及通过对其他数据库的交叉引用来提供其他增值信息。 Uniprot由三个主要组件组成，每个组件都针对不同的用途进行了优化：Uniprot档案，Uniprot知识库和UniProt参考群集。最近，已将由宏基因组和环境序列组成的其他组成部分添加到Uniprot中，以确保及时的序列可用。
The ability to store and interconnect all available information on proteins is crucial to modern biological research. Accordingly, the Universal Protein Resource (UniProt) plays an increasingly important role by providing a stable, comprehensive, freely accessible central resource on protein sequences and functional annotation. UniProt is produced by the UniProt Consortium, formed in 2002 by the European Bioinformatics Institute (EBI), the Protein Information Resource (PIR) and the Swiss Institute of Bioinformatics (SIB). The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, development of a user-friendly UniProt web site and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of three major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledgebase and the UniProt Reference Clusters. An additional component consisting of metagenomic and environmental sequences has recently been added to UniProt to ensure availability of such sequences in a timely fashion.