Radiation response of endothelial cells in vitro.
Radiation response of endothelial cells in vitro.
复制标题
内皮细胞的体外辐射反应。
DOI：
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发表时间：
1985
影响因子：
2.6
通讯作者：
M. Laverick
中科院分区：
文献类型：
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作者：
M. Penhaligon;M. Laverick
目前关于间质组织在辐射后晚期正常组织损伤的病理学中的作用存在一些争议。如果间质的辐射损伤确实带来了晚期辐射效应，那么了解该组织的辐射反应是必不可少的。对构成基质组织的细胞类型的辐射反应的研究受到该组织缓慢增殖特性的阻碍，并且类似于对细胞如骨髓或肠隐窝细胞的单细胞存活研究的体内方法尚未开发。另一个需要考虑的因素是，基质（血管和结缔组织）的结构不同，因此根据其供应的器官的不同要求，总体放射敏感性也可能不同。
There is some controversy at the moment concerning the role of stromal tissue in the pathology of late normal tissue damage after irradiation. If radiation damage to stroma does bring about late radiation effects, knowledge of the radiation response of this tissue is essential. Studies on the radiation response of cell types which make up stromal tissue are hampered by the slowly proliferating character of the tissue, and in-vivo methods analogous to the single-cell survival studies of cells such as bone marrow or intestinal crypt cells have yet to be developed. Another factor to be considered is that stroma (vascular and connective tissues) will differ in structure and hence possibly also in overall radiosensitivity according to the different requirements of the organs it supplies.