Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: A randomised double-blind, crossover study
Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: A randomised double-blind, crossover study
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DOI：
10.1016/j.clnu.2009.05.002
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发表时间：
2009-12-01
影响因子：
6.3
通讯作者：
Fearon, Kenneth C. H.
中科院分区：
文献类型：
--
作者：
Lobo, Dileep N.;Hendry, Paul O.;Fearon, Kenneth C. H.
背景和目的：术前饥饿有许多不良影响，但禁食的最短时间受到胃排空的限制，胃排空可能取决于饲料的营养成分、粘度和渗透压。我们比较了健康志愿者中两种类型的术前代谢预处理饮料[口服营养补充剂（ONS）（Fresenius Kabi，德国）和 preOp（R）（Nutricia Clinical Care，英国）]的胃排空情况。方法：以随机交叉方式在 3 个不同的场合对 20 名（10 名男性，10 名女性）健康成年志愿者进行研究。志愿者摄入400毫升preOp（R），这是一种透明碳水化合物饮料（CCD）（50克碳水化合物，0克蛋白质），70克ONS（50克碳水化合物和15克谷氨酰胺）溶解在水中，总体积为400毫升（ONS400）和300毫升（ONS300）。使用磁共振成像测量胃排空时间。结果：与 ONS400 和 ONS300 相比，CCD 的平均 (95% Cl) T-50 和 T-100 胃排空时间显着较低 (p < 0.001)。 CCD、ONS400 和 ONS300 的 T50 分别为 47 (39-55)、78 (69-87) 和 81 (70-92) 分钟。相应地，T-100 为 94 (79-110)、156 (138-173) 和 162 (140-184) 分钟。 CCD 后 120 分钟、ONS400 和 ONS300 后 180 分钟残余胃容量恢复到基线。结论：与 ONS400 和 ONS300 相比，CCD 的胃排空速度更快，这表明健康志愿者的胃排空可能更依赖于营养负荷，而不是容量或粘度。虽然术前给予 CCD 2 小时是安全的，但 ONS400 和 ONS300 应在术前至少给予 3 小时。 (C) 2009 Elsevier Ltd 和欧洲临床营养与代谢学会。版权所有。
Background & aims: Preoperative starvation has many undesirable effects but the minimum length of fasting is limited by gastric emptying, which may be dependent on nutrient content, viscosity and osmolarity of the feed. We compared the gastric emptying of two types of preoperative metabolic preconditioning drinks [Oral Nutritional Supplement (ONS) (Fresenius Kabi, Germany) and preOp (R) (Nutricia Clinical Care, UK)] in healthy volunteers.Methods: Twenty (10 male, 10 female) healthy adult volunteers were studied on 3 separate occasions in a randomised crossover manner. Volunteers ingested 400 ml preOp (R), which is a clear carbohydrate drink (CCD) (50 g carbohydrate, 0 g protein), 70 g ONS (50 g carbohydrate and 15 g glutamine) dissolved in water to a total volume of 400 ml (ONS400) and 300 ml (ONS300). Gastric emptying time was measured using magnetic resonance imaging.Results: Mean (95% Cl) T-50 and T-100 gastric emptying times for CCD were significantly lower (p < 0.001) compared with ONS400 and ONS300. T50 was 47 (39-55), 78 (69-87) and 81 (70-92) min for CCD, ONS400 and ONS300 respectively. Correspondingly T-100 was 94 (79-110),156 (138-173) and 162 (140-184) min. Residual gastric volumes returned to baseline 120 min after CCD and 180 min after ONS400 and ONS300.Conclusions: The faster gastric emptying for CCD compared to ONS400 and ONS300 signifies that gastric emptying may be more dependent on nutrient load than volume or viscosity in healthy volunteers. While it is safe to give CCD 2 h preoperatively, ONS400 and ONS300 should be given at least 3 h preoperatively. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.