Clinicopathological characteristics and immunophenotypes of primary central nervous system lymphoma
Clinicopathological characteristics and immunophenotypes of primary central nervous system lymphoma
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原发性中枢神经系统淋巴瘤的临床病理特征及免疫表型
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发表时间：
2012
期刊：
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通讯作者：
Z. Xuan
中科院分区：
文献类型：
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作者：
Z. Xuan
目的探讨原发性中枢神经系统淋巴瘤（PCNSL）的临床病理特征及免疫表型方法回顾性分析2007年4月至2012年5月期间经组织病理学证实的16例PCNSL患者的临床病理资料，采用免疫组化方法分析免疫表型。结果16例PCNSL患者年龄7 ~ 74岁，平均52.3岁。肿瘤细胞呈弥漫性分布，血管周围呈袖状排列，免疫组化结果显示：CD 45（+）、GFAP（-）15例，CD 20（+）10例，CD 25（CD 79 a（+）12例，MUM 1（+）13例，提示均为B淋巴细胞来源，16例PCNSL中弥漫大B细胞淋巴瘤（11例）是PCNSL的主要组织学类型。
Purpose To study the clinicopathological characteristics and immunophenotypes of primary central nervous system lymphoma(PCNSL).Methods The clinicopathological data of 16 histopathologically proven cases of PCNSL were retrospectively analyzed from April 2007 to May 2012.Immunophenotypes were analyzed by immunohistochemistry.Results The age of 16 PCNSL patients ranged from 7 to 74 years with an average age of 52.3 years.The ratio of male to female was 2.2 ∶ 1.Frontal lobe and occipital lobe were the most common sites of involvement.Diffuse distribution and perivascular arrangement in a sleevelet-like pattern of the tumor cells were the pathological characteristics of PCNSL.Immunohistochemical results showed CD45(+) and GFAP(-) in all cases,CD20(+) in 15 cases,CD79a(+) in 12 cases and MUM1(+) in 13 cases,suggesting B lymphocyte origin of all cases.Diffuse large B-cell lymphoma(11 cases in 16 cases of PCNSL) was the major histological pattern of PCNSL.Conclusion Diffuse large B-cell lymphoma is the major pathological type of PCNSL,pathological examination and immunophenotyping are the gold standard for diagnosing PCNSL.