Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase‐1 in patients with paraquat poisoning
Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase‐1 in patients with paraquat poisoning
复制标题
百草枯中毒患者IV型胶原和金属蛋白酶组织抑制剂-1浓度的变化
DOI：
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发表时间：
2001
影响因子：
3.3
通讯作者：
H. Koide
中科院分区：
文献类型：
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作者：
Tsukasa Nakamura;C. Ushiyama;N. Shimada;Kayo Hayashi;I. Ebihara;Masataka Suzaki;H. Koide
呼吸衰竭是百草枯中毒患者死亡的主要原因之一。在百草枯中毒的肺中，会发生异常的细胞外基质调节。本研究的目的是确定百草枯中毒过程中血清IV型胶原和金属蛋白酶组织抑制因子-1(TIMP-1)的浓度是否发生变化，以及血液灌流治疗是否影响这些浓度。21例患者在服用百草枯后3h内入院，所有患者均接受直接血液灌流治疗。21名患者中有5名存活，16名患者在28天内死亡。治疗前死亡者血浆百草枯浓度(5 74 0±380µg L−1)与存活者血浆百草枯浓度(5 92 0±2 80µg L−1)无显著差异。在血液灌流第5天，死亡者和存活者的血清IV型胶原和TIMP-1浓度无明显变化(IV型胶原，90.4±3.6ngml−1；TIMP-1,172.2±7.0ngmlTIMP 1)和第5天(IV型胶原，92.6±4.2ngml−1；TIMP-1,174.2±7.2ngml−1)。相反，第5天死亡组(IV型胶原，143.6±7.8mgmlTIMP-1；TIMP-1,246.8±13.6ngml−1)显著高于第1天(IV型胶原，88.4ngml−1，P<0.01；TIMP-1,170.6±9.2ngml−1，P<0.05)。这些数据表明，血清IV型胶原和TIMP-1的浓度可能是百草枯中毒患者发生呼吸衰竭的有用指标。版权所有©2001 John Wiley&Sons，Ltd.
Respiratory failure is one of the major causes of death in patients with paraquat poisoning. In paraquat‐poisoned lungs, abnormal extracellular matrix regulation occurs. The aim of the present study is to determine whether serum concentrations of type IV collagen and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) are altered during the course of paraquat poisoning and whether haemoperfusion therapy affects these concentrations. Twenty‐one patients were admitted within 3 h after ingestion of paraquat and all patients received direct haemoperfusion therapy. Five out of 21 patients survived and 16 patients died within 28 days. Plasma paraquat concentrations in non‐survivors (5740 ± 380 µg l−1) were not significantly different from those in survivors ( 5920 ± 280 µg l−1) before treatment. Haemoperfusion reduced these concentrations in both non‐survivors (120 ± 7 µg l−1) as well as survivors (136 ± 9 µg l−1) on day 5. Serum concentrations of type IV collagen and TIMP‐1 in survivors showed little change between day 1 (type IV collagen, 90.4 ± 3.6 ng ml−1; TIMP‐1, 172.2 ± 7.0 ng ml−1) and day 5 (type IV collagen, 92.6 ± 4.2 ng ml−1; TIMP‐1, 174.2 ± 7.2 ng ml−1). In contrast, these concentrations in non‐survivors on day 5 (type IV collagen, 143.6 ± 7.8 mg ml−1; TIMP‐1, 246.8 ± 13.6 ng ml−1) were significantly higher than those on day 1 (type IV collagen, 88.4 ± 4.2 ng ml−1, P < 0.01; TIMP‐1, 170.6 ± 9.2 ng ml−1, P < 0.05). These data suggest that serum concentrations of type IV collagen and TIMP‐1 may be useful indicators for the development of respiratory failure in patients with paraquat poisoning. Copyright © 2001 John Wiley & Sons, Ltd.
DOI：
10.1164/ajrccm/140.6.1693
发表时间：
1989-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
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作者：
KUHN, C;BOLDT, J;MCDONALD, JA
通讯作者：
MCDONALD, JA