Clinical significance of bcl-2 gene expression in human breast cancer tissues
Clinical significance of bcl-2 gene expression in human breast cancer tissues
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DOI：
10.1023/a:1005760013810
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发表时间：
1997-01-01
影响因子：
3.8
通讯作者：
Masaoka, A
中科院分区：
文献类型：
--
作者：
Kobayashi, S;Iwase, H;Masaoka, A
对 142 名日本乳腺癌患者的新鲜冷冻肿瘤组织中的雌激素受体 (ER) 和 bcl-2 (Bcl-2)（一种凋亡保护性癌基因）在正常和癌性乳腺导管上皮细胞中的表达进行了免疫组织化学检查。分析患者的临床病理特征和无病生存率。在乳腺癌的导管内成分中也观察到这两种蛋白的表达。尽管不到1%的正常导管上皮表达ER，但Bcl-2广泛表达。这两种蛋白在乳腺癌中的表达显着相关。它们的表达与肿瘤大小显着负相关，但与淋巴结状态无关。浸润性导管癌的乳头管状亚型表达 Bcl-2 的频率明显高于实性管状亚型。表达 Bcl-2 的肿瘤患者的存活率明显高于表达减少的肿瘤患者。乳头状筛状型导管内成分比固体粉刺型更频繁地表达这两种蛋白质。
The expression of estrogen receptor (ER) and bcl-2 (Bcl-2), an apoptosis protective oncogene, in normal and cancerous breast duct epithelia was immunohistochemically examined in fresh frozen tumor tissues from 142 Japanese breast cancer patients. The clinico-pathological characteristics and the disease free survival of the patients were analyzed. The expression of both the proteins was also observed in intraductal components of breast cancer. Although less than 1% of normal duct epithelia expressed ER, Bcl-2 was diffusely expressed. The expression of both these proteins in breast cancer significantly correlated with each other. Their expression significantly correlated negatively with tumor size but not with lymph node status. The papillo-tubular sub-type of invasive ductal carcinoma expressed Bcl-2 significantly more frequently than the solid-tubular sub-type. Patients with Bcl-2 expressing tumors survived without recurrence significantly more than those with tumors exhibiting reduced expression. Papillary-cribriform type intraductal components expressed both those proteins more often than the solid-comedo type.