Interpretation of the human skin biotribological behaviour after tape stripping
Interpretation of the human skin biotribological behaviour after tape stripping
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DOI：
10.1098/rsif.2010.0672
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发表时间：
2011-07-06
影响因子：
3.9
通讯作者：
Nicoli, S.
中科院分区：
文献类型：
--
作者：
Pailler-Mattei, C.;Guerret-Piecourt, C.;Nicoli, S.
本研究涉及胶带剥离后的人皮肤生物摩擦学行为的修改。胶带剥离程序包括在皮肤表面上依次施加和移除胶带，以便移除角质层（SC）层，角质层（SC）层使皮肤表面带电。胶带剥离产生的皮肤电荷通过增加皮肤摩擦系数的粘附分量而高度改变皮肤摩擦行为。有人建议将摩擦粘附分量重写为两项之和：第一项经典粘附项取决于固有剪切强度τ（0），第二项取决于电剪切强度τ（0）。实验结果允许估计电剪切强度τ（τ）的数值。此外，一个平面电容器模型与内部的介电材料被用来模拟实验系统。该物理模型允许评估摩擦电力和电剪切强度值，以计算胶带剥离后的表面摩擦系数。胶带剥离后的皮肤摩擦系数的实验值和理论值之间的比较表明了电荷对皮肤生物摩擦学行为的重要性。胶带剥离在皮肤表面上产生的静电荷可能能够高度改变制剂与皮肤表面的相互作用及其铺展性能。这种现象通常被忽视，应考虑到，因为它可能涉及药物吸收的改变。
The present study deals with the modification of the human skin biotribological behaviour after tape stripping. The tape-stripping procedure consists in the sequential application and removal of adhesive tapes on the skin surface in order to remove stratum corneum (SC) layers, which electrically charges the skin surface. The skin electric charges generated by tape stripping highly change the skin friction behaviour by increasing the adhesion component of the skin friction coefficient. It has been proposed to rewrite the friction adhesion component as the sum of two terms: the first classical adhesion term depending on the intrinsic shear strength, tau(0), and the second term depending on the electric shear strength, tau(elec). The experimental results allowed to estimate a numerical value of the electric shear strength tau(elec). Moreover, a plan capacitor model with a dielectric material inside was used to modelize the experimental system. This physical model permitted to evaluate the friction electric force and the electric shear strength values to calculate the skin friction coefficient after the tape stripping. The comparison between the experimental and the theoretical value of the skin friction coefficient after the tape stripping has shown the importance of the electric charges on skin biotribological behaviour. The static electric charges produced by tape stripping on the skin surface are probably able to highly modify the interaction of formulations with the skin surface and their spreading properties. This phenomenon, generally overlooked, should be taken into consideration as it could be involved in alteration of drug absorption.