BOVINE VIRAL DIARRHEA VIRUS-INFECTIONS IN PIGLETS BORN TO SOWS VACCINATED AGAINST SWINE FEVER WITH CONTAMINATED VACCINE
BOVINE VIRAL DIARRHEA VIRUS-INFECTIONS IN PIGLETS BORN TO SOWS VACCINATED AGAINST SWINE FEVER WITH CONTAMINATED VACCINE
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DOI：
10.1016/s0034-5288(18)30920-2
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发表时间：
1988-09-01
影响因子：
2.4
通讯作者：
TERPSTRA, C
中科院分区：
文献类型：
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作者：
WENSVOORT, G;TERPSTRA, C
在8个农场中，检测到仔猪先天性瘟病毒感染，可追溯至母猪接种猪瘟（SF）疫苗。从仔猪中分离的病毒未被抗猪瘟病毒（SFV）的单克隆抗体（MCA）识别，并显示为牛病毒性腹泻病毒（BVDV）或边境病病毒。在这些农场使用的疫苗批次中无法证明预期的“中国”SFV毒株。相反，回收了污染的瘟病毒，其不被针对SFV的MCA识别。该污染物对羔羊具有出乎意料的高毒力，并在羔羊和猪中诱导抗BVDV抗体。因此，可将其表征为BVDV或边界病病毒。
On eight farms a congenital pestivirus infection in piglets was detected which could be traced to vaccination of the dams against swine fever (SF). Viruses isolated from the piglets were not recognised by monoclonal antibodies (MCAs) against swine fever virus (SFV) and were shown to be bovine viral diarrhoea virus (BVDV) or Border disease virus. The expected ''Chinese'' strain of SFV could not be demonstrated in the batch of vaccination that had been used on these farms. Instead, a contaminating pestivirus was recovered which was not recognised by the MCAs against SFV. The contamnant had an unexpectedly high virulence for lambs and induced antibodies against BVDV in lambs and pigs. It could, therefore, be characterised as BVDV or Border disease virus.