Integrins in platelet activation
Integrins in platelet activation
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DOI：
10.1111/j.1538-7836.2009.03370.x
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发表时间：
2009-07-01
影响因子：
10.4
通讯作者：
Elvers, M.
中科院分区：
文献类型：
--
作者：
Nieswandt, B.;Varga-Szabo, D.;Elvers, M.
β 1和β 3整联蛋白家族的异二聚体受体介导止血和血栓形成中的血小板粘附和聚集。在静息血小板中，整合素以低亲和力状态表达，但它们转变为高亲和力状态，并响应细胞活化而有效地结合其配体。本文综述了近年来血小板整合素的功能调节和（病理）生理意义的研究进展，特别是在转基因小鼠的研究。现在认识到，β 1和β 3整联蛋白在粘附过程中具有部分冗余的作用，并且它们的活化由类似的机制调节，包括Ca 2+依赖性和非依赖性信号传导事件以及talin-1和kindlin-3在末端活化步骤中的基本功能。
Heterodimeric receptors of the beta 1 and beta 3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation. This review summarizes recent advances in understanding the functional regulation and (patho-) physiological significance of individual platelet integrins with a special focus on studies in genetically modified mice. It is now recognized that beta 1 and beta 3 integrins have partially redundant roles in the adhesion process and that their activation is regulated by similar mechanisms, involving Ca2+-dependent and -independent signaling events and essential functions of talin-1 and kindlin-3 in the terminal activation step.