ORGANIZATION OF CAT ANTERIOR PARIETAL CORTEX - RELATIONS AMONG CYTOARCHITECTURE, SINGLE NEURON FUNCTIONAL-PROPERTIES, AND INTER-HEMISPHERIC CONNECTIVITY
ORGANIZATION OF CAT ANTERIOR PARIETAL CORTEX - RELATIONS AMONG CYTOARCHITECTURE, SINGLE NEURON FUNCTIONAL-PROPERTIES, AND INTER-HEMISPHERIC CONNECTIVITY
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DOI：
10.1152/jn.1981.45.4.667
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
METZ, CB
中科院分区：
文献类型：
--
作者：
MCKENNA, TM;WHITSEL, BL;METZ, CB
在家猫大脑顶叶前皮质进行微电极穿透。只要有可能，它们就被放置在这样的位置，以便遇到皮质神经元的长序列。在记录单个神经元活动的每个位置，获得感受场(RF)位置和子通道属性的描述。观察结果被重建成一张地图，显示了顶前地形组织和细胞结构之间的关系。在第二系列实验中，用辣根过氧化物酶(HRP)逆行运输的方法显示顶前神经元的位置，投射到对侧大脑半球的同源野。根据每个实验中提供的数据，可以根据大脑半球间的连通性和细胞结构来区分大脑皮层区域之间的关系。具有半球间联系的顶前神经元的分布图与顶前地形图密切相关。不同图谱的直接比较揭示了细胞结构、半球间连通性和功能组织之间的关系。全身麻醉药减小了RF的大小，并改变了在没有全身麻醉的情况下观察到的顶前神经元的RF的形态。这些药物的其他作用包括提高自然刺激诱发神经元放电的阈值，以及降低受控自然刺激引起的单个神经元反应的幅度。静脉注射后获得的射频数据。全身麻醉药氯胺酮(10-40 mg/kg)和甲氧己胺(2-4 mg/kg)的给药似乎与在没有全麻的情况下根据RF数据生成的顶前区地形图不一致，该数据也与所提出的地形图、大脑半球间连通性和细胞结构之间的关系不一致。
Microelectrode penetrations are made in the anterior parietal cerebral cortex of domestic cats. Whenever possible they are placed so that long sequences of cortical neurons are encountered. At each location where the activity of a single neuron is recorded, a description of receptive-field (RF) location and submodality properties is obtained. The observations are reconstructed to a map showing the relations between anterior parietal topographical organization and cytoarchitecture. In a 2nd series of experiments the method of retrograde transport of horseradish peroxidase (HRP) is used to reveal the locations of anterior parietal neurons, projecting to the homotopic field in the opposite hemisphere. A map of the relations between cortical territories, distinguishable on the basis of interhemispheric connectivity and cytoarchitecture, is generated from the data provided in each experiment. The maps of the distribution of anterior parietal neurons having interhemispheric connections correspond closely with the map of anterior parietal topographic organization. Direct comparison of the different maps reveals the relations among cytoarchitecture, interhemispheric connectivity and functional organization. General anesthetics reduce RF size, and alter the configuration of the RF of anterior parietal neurons from that observed in the absence of general anesthesia. Other effects of these agents include elevation of the threshold for eliciting neuronal discharge with natural stimuli, and reduction of the amplitude of single-neuron response evoked by controlled natural stimulation. The RF data obtained after i.v. administration of the general anesthetics ketamine (10-40 mg/kg) and methohexital (2-4 mg/kg) appear inconsistent with the map of anterior parietal topographic organization, generated from RF data in the absence of general anesthesia; the data is also inconsistent with the proposed relations among topographic organization, interhemispheric connectivity and cytoarchitecture.