Aversive experiences are associated with a rapid and transient activation of ERKs in the rat hippocampus.
Aversive experiences are associated with a rapid and transient activation of ERKs in the rat hippocampus.
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DOI：
10.1006/nlme.2000.4000
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发表时间：
2002-01-01
影响因子：
2.7
通讯作者：
Medina, JH
中科院分区：
文献类型：
--
作者：
Alonso, M;Viola, H;Medina, JH
丝裂原激活蛋白激酶 (MAPK) 的细胞外信号调节激酶 (ERK) 家族已被证明参与记忆形成。我们最近发现海马 ERK/MAPK 级联是大鼠抑制性回避训练记忆形成所必需的。在这里，我们报道了这种学习任务伴随着海马 p44 MAPK 磷酸化的快速增加。一次轻微的足部电击产生了类似的效果，连续三次足部电击激发了 p44 和 p42 MAPK 的激活。相比之下，短暂暴露于训练箱或习惯于开放场地并不会改变海马 ERK/MAPK 水平。总之，这些研究结果表明，厌恶行为经历会导致海马体中 ERK/MAPK 快速而短暂的激活。 (C) 2001 年爱思唯尔科学。
The extracellular signal-regulated kinases (ERKs) family of mitogen-activated protein kinases (MAPKs) has been shown to participate in memory formation. We recently found that a hippocampal ERK/MAPK cascade is required for memory formation of an inhibitory avoidance training in rats. Here we reported that this learning task is accompanied by a rapid increase in the phosphorylation of hippocampal p44 MAPK. A single mild foot shock produced a similar effect and three consecutive foot shocks provoked the activation of both p44 and p42 MAPKs. In contrast, a brief exposure to the training box or the habituation to an open field did not alter hippocampal ERK/MAPK levels. Together, these findings indicate that aversive behavioral experiences induced a rapid and transient activation of ERK/MAPKs in the hippocampus. (C) 2001 Elsevier Science.