Associations between depressive symptoms and inflammatory/hemostatic markers in women during the menopausal transition
Associations between depressive symptoms and inflammatory/hemostatic markers in women during the menopausal transition
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DOI：
10.1097/01.psy.0000256574.30389.1b
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发表时间：
2007-02-01
影响因子：
3.3
通讯作者：
Sowers, Mary Fran
中科院分区：
文献类型：
--
作者：
Matthews, Karen A.;Schott, Laura L.;Sowers, Mary Fran
目的：探讨更年期妇女抑郁症状与炎症和止血指标之间的关系。方法：对参加《全国妇女健康研究》(SWAN)的3292名妇女进行为期5年的随访，并在随访期内对抑郁和高敏C反应蛋白、VIIC因子、纤维蛋白原、纤溶酶原激活物抑制物-1(PAI-1)和组织型纤溶酶原激活物抗原(tPA-Ag)进行4次检测。在研究开始时，女性处于围绝经期前或早期状态，是高加索人、非裔美国人、西班牙裔、日本人或中国人。结果：未经调整的纵向混合回归模型显示，在5年期间，抑郁症状越重与纤维蛋白原、PAM和tPA-Ag水平越高有关，均P
Objective: To test whether depressive symptoms are related to inflammatory and hemostatic markers in women approaching menopause. Methods: A total of 3292 women enrolled in the Study of Women's Health Across the Nation (SWAN) were followed for five years and had measures of Center for Epidemiologic Studies-Depression and high sensitivity C-reactive protein, Factor VIIc, fibrinogen, plasminogen activator inhibitor Type I (PAI-1), and tissue-type plasminogen activator antigen (tPA-ag) up to four times during the follow-up period. Women were pre- or early perimenopausal status at study entry and were of Caucasian, African American, Hispanic, Japanese, or Chinese race/ethnicity. Results: Unadjusted longitudinal mixed regression models showed that over a 5-year period, higher depressive symptoms were related to higher fibrinogen, PAM, and tPA-ag levels, all p