Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
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DOI：
10.1109/jstqe.2009.2037723
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发表时间：
2010-07-01
影响因子：
4.9
通讯作者：
Glunde, Kristine
中科院分区：
文献类型：
--
作者：
Chen, Yu;Yuan, Shuai;Glunde, Kristine
多模态成像是当前生物光子学成像技术发展的趋势之一。本文简要综述了目前在宏观、微观和介观（或毫米）尺度上的多模态生物光子学成像平台。我们还提出了一种结合光学相干层析成像和线扫描荧光层流光学层析成像系统，用于毫米级成像深度的结构和分子成像。本文介绍了用荧光染料Cy5.5填充毛细管模体和人乳腺癌异种移植模型的实验结果。
Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.