Small molecule inhibitors of HIV RT Ribonuclease H
Small molecule inhibitors of HIV RT Ribonuclease H
复制标题
DOI：
10.1016/j.bmcl.2009.10.043
复制
发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
O'Connell, John
中科院分区：
文献类型：
--
作者：
Di Grandi, Martin;Olson, Matthew;O'Connell, John
Two classes of compounds, thiocarbamates 1 and triazoles 2, have been identified as HIV RT RNase H inhibitors using a novel FRET-based HTS assay. The potent analogs in each series exhibited selectivity and were active in cell-based assays. In addition, saturable, 1: 1 stoichiometric binding to target was established and time of addition studies were consistent with inhibition of RT-mediated HIV replication. (C) 2009 Elsevier Ltd. All rights reserved.
