THE EFFECTS OF AGE ON THE N200 COMPONENT OF THE AUDITORY EVENT-RELATED POTENTIALS
THE EFFECTS OF AGE ON THE N200 COMPONENT OF THE AUDITORY EVENT-RELATED POTENTIALS
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DOI：
10.1016/0926-6410(93)90023-x
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发表时间：
1993-10-01
期刊：
影响因子：
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通讯作者：
OHTAHARA, S
中科院分区：
文献类型：
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作者：
ENOKI, H;SANADA, S;OHTAHARA, S
本研究旨在确定发育和衰老对儿童期至成年期事件相关电位 N200 的影响。记录了 164 名年龄从 4 岁到 77 岁的正常受试者的事件相关电位。 164 名受试者中共有 127 名受试者表现出 N200 峰值。 N200表现出明显的发育变化。在儿童时期，N200潜伏期随着年龄的增长而迅速下降，在16岁时达到最低值（217+/-17.3ms），而在成年期则随着年龄的增长而逐渐延长。 5至15岁受试者的潜伏期/年龄斜率是-9.03毫秒/年，而16至77岁受试者的潜伏期/年龄斜率是+0.97毫秒/年。N200-P300峰间潜伏期在所有年龄组中保持恒定，没有显示出与年龄相关的变化。 N200 振幅随着年龄的增加而降低。 19 名年轻病例在频繁刺激下表现出 N200 峰值。他们的年龄从5岁到17岁不等。我们的研究表明，N200 对于评估中枢神经系统的发育和衰老过程很有价值。本研究结果可作为临床实践的规范数据。
This study was undertaken to determine the effects of development and aging on N200 of event-related potentials from childhood to adulthood. Event-related potentials were recorded from 164 normal subjects ranging in age from 4 to 77 years. A total of 127 of the 164 subjects demonstrated N200 peaks. N200 showed marked developmental changes. During childhood, the N200 latency decreased rapidly with age to the minimum (217 +/- 17.3 ms) at 16 years of age, while it was prolonged gradually with age during adulthood. The latency/age slope in the subjects from 5 to 15 years of age was -9.03 ms/year, while + 0.97 ms/year in those from 16 to 77. The N200-P300 interpeak latency remained constant in all age groups and showed no age-related changes. The N200 amplitude decreased as age increased. Nineteen young cases showed N200 peaks to the frequent stimuli. Their ages ranged from 5 to 17 years. Our study suggests that N200 is valuable in evaluating the developmental and aging processes in the central nervous system. The results of this study could be used as normative data in clinical practices.