Effects of arterial load variations on dynamic arterial elastance: an experimental study
Effects of arterial load variations on dynamic arterial elastance: an experimental study
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DOI：
10.1093/bja/aex070
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发表时间：
2017-06-01
影响因子：
9.8
通讯作者：
Cecconi, M.
中科院分区：
文献类型：
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作者：
Monge Garcia, M. I.;Guijo Gonzalez, P.;Cecconi, M.
背景动态动脉弹性（Ea（dyn）），脉压变异度（PPV）和每搏输出量变异度（SVV）之间的关系，已被建议作为动脉负荷的功能评估。本研究的目的是评估急性药理学变化、液体给药和出血期间动脉负荷变化对Eadyn的影响。对18只麻醉、机械通气的新西兰兔进行了研究。分别用苯丙氨酸（n=9）和硝普钠（n=9）引起动脉负荷变化。此后，动物接受液体推注（10 ml/kg），然后逐步放血（失血量：15 ml/kg）。采用线性混合效应模型分析动脉负荷和心脏变量对PPV、SVV和Eadyn的影响。输注苯肾上腺素后，平均（SD）Eadyn从0.89（0.14）降至0.49（0.12），P
Background. Dynamic arterial elastance (Ea(dyn)), the relationship between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional assessment of arterial load. The aim of this study was to evaluate the impact of arterial load changes during acute pharmacological changes, fluid administration, and haemorrhage on Eadyn.Methods. Eighteen anaesthetized, mechanically ventilated New Zealand rabbits were studied. Arterial load changes were induced by phenylephrine (n=9) or nitroprusside (n=9). Thereafter, animals received a fluid bolus (10 ml kg(-1)), followed by stepwise bleeding (blood loss: 15 ml kg(-1)). The influence of arterial load and cardiac variables on PPV, SVV, and Eadyn was analysed using a linear mixed-effects model analysis.Results. After phenylephrine infusion, mean (SD) Eadyn decreased from 0.89 (0.14) to 0.49 (0.12), P