MOUSE MONOCLONAL-ANTIBODIES DIRECT PHAGOCYTOSIS OF TUMOR-CELLS BY HUMAN-MONOCYTES
MOUSE MONOCLONAL-ANTIBODIES DIRECT PHAGOCYTOSIS OF TUMOR-CELLS BY HUMAN-MONOCYTES
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DOI：
10.1016/0145-2126(86)90344-9
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发表时间：
1986-01-01
影响因子：
2.7
通讯作者：
HEKMAN, A
中科院分区：
文献类型：
--
作者：
CALAFAT, J;JANSSEN, H;HEKMAN, A
发现人外周血单核细胞能够吞噬包被小鼠单克隆抗体（MoAbs）的人b -非霍奇金淋巴瘤（NHL）细胞。MoAbs使用肿瘤细胞表面免疫球蛋白（Ig）上公认的独特型决定因子。IgG1和IgG2a亚类的moab在诱导吞噬方面同样有效。单核细胞与来自人或小鼠血清的热聚集的Ig预孵育在相同程度上抑制了吞噬作用，这表明单核细胞上的Fc受体参与了与人和小鼠抗体的结合。
Human peripheral blood monocytes were found to be capable of phagocytising human B-non Hodgkin''s lymphoma (NHL) cells coated with mouse monoclonal antibodies (MoAbs). The MoAbs used recognized idiotypic determinants on the surface immunoglobulin (Ig) of the tumor cells. MoAbs of IgG1 and IgG2a subclass were equally effective in inducing phagocytosis. Preincubation of the monocytes with heat aggregated Ig from human or mouse serum inhibited phagocytosis to the same degree, suggesting involvement of an Fc receptor on the monocytes that binds both human and mouse antibodies.