Stress responses to repeated exposure to a combined physical and social evaluative laboratory stressor in young healthy males
Stress responses to repeated exposure to a combined physical and social evaluative laboratory stressor in young healthy males
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DOI：
10.1016/j.psyneuen.2015.09.025
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发表时间：
2016-01-01
影响因子：
3.7
通讯作者：
Dye, L.
中科院分区：
文献类型：
--
作者：
Boyle, N. B.;Lawton, C.;Dye, L.
重复暴露于同型实验室心理社会应激源通常会在人类下丘脑-垂体-肾上腺（HPA）轴介导的应激反应中引发快速习惯化。然而，新出现的证据表明，身体压力和社会评价威胁的结合可能足以削弱这种反应习惯化。在反复暴露于组合的身体和社会评价应激方案之后，评估神经内分泌、心血管和主观应激反应，以检查在这种情况下的习惯化反应动态。1993）和社会评价的冷加压任务（SECPT;施瓦贝等，2008）在联合应激方案中施用。唾液皮质醇，心血管和主观应激反应的非应激控制和重复应激暴露间隔6周，在男性（N=24）进行了检查，在交叉的方式。应激暴露导致所有的应激参数显着升高。与通常报道的皮质醇反应的习惯化相反，证明了一种可比较的应激后反应。皮质醇、心率和主观压力反应的特点也是对重复压力暴露的预期反应增强。重复暴露的血压反应相对一致。研究结果表明，结合物理和社会评价的压力是一个潜在的有用的方法，研究设计，需要重复介绍一个同型压力。(C)2015爱思唯尔有限公司版权所有。
Repeated exposure to homotypic laboratory psychosocial stressors typically instigates rapid habituation in hypothalamic-pituitary-adrenal (HPA) axis-mediated stress responses in humans. However, emerging evidence suggests the combination of physical stress and social evaluative threat may be sufficient to attenuate this response habituation. Neuroendocrine, cardiovascular and subjective stress responses following repeated exposure to a combined physical and social evaluative stress protocol were assessed to examine the habituation response dynamic in this context.The speech task of the Trier social stress test (TSST; Kirschbaum et al., 1993) and the socially evaluated cold pressor task (SECPT; Schwabe et al., 2008) were administered in a combined stressor protocol. Salivary cortisol, cardiovascular and subjective stress responses to a non-stress control and repeat stressor exposure separated by six weeks were examined in males (N=24) in a crossover manner.Stressor exposure resulted in significant elevations in all stress parameters. In contrast to the commonly reported habituation in cortisol response, a comparable post-stress response was demonstrated. Cortisol, heart rate and subjective stress responses were also characterised by a heightened response in anticipation to repeated stress exposure. Blood pressure responses were comparatively uniform across repeated exposures. Findings suggest a combined physical and social evaluative stressor is a potentially useful method for study designs that require repeated presentation of a homotypic stressor. (C) 2015 Elsevier Ltd. All rights reserved.