Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System.
Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System.
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DOI：
10.3389/fphys.2021.686249
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发表时间：
2021
影响因子：
4
通讯作者：
Carneiro-Ramos MS
中科院分区：
文献类型：
--
作者：
Falconi CA;Junho CVDC;Fogaça-Ruiz F;Vernier ICS;da Cunha RS;Stinghen AEM;Carneiro-Ramos MS
肾脏和心脏共享功能，共同目标是维持体内平衡。当肾损伤发生时，许多化合物，即所谓的“尿毒症潴留溶质”或“尿毒症毒素”，会积聚在针对其他组织的循环中。尿毒症毒素如硫酸对甲苯酯、硫酸吲哚酚和无机磷酸盐的积累会导致大量身体功能丧失。尽管尿毒症毒素的概念可以追溯到 20 世纪 60 年代，但导致肾脏和心血管损伤的分子机制尚不清楚。此外，最大的毒性作用似乎是由难以通过透析去除的化合物引起的。考虑到肾脏和心血管功能之间的密切关系，了解尿毒症毒素的产生、清除和总体影响所涉及的机制对于了解心血管系统的病理学极为相关。因此，本研究的主要重点是对尿毒症毒素对心血管系统的影响进行广泛的综述，介绍该主题的最新技术以及与慢性肾病患者治疗相关的临床意义，慢性肾病代表着患有心脏合并症的患者的高死亡率。
The kidneys and heart share functions with the common goal of maintaining homeostasis. When kidney injury occurs, many compounds, the so-called “uremic retention solutes” or “uremic toxins,” accumulate in the circulation targeting other tissues. The accumulation of uremic toxins such as p-cresyl sulfate, indoxyl sulfate and inorganic phosphate leads to a loss of a substantial number of body functions. Although the concept of uremic toxins is dated to the 1960s, the molecular mechanisms capable of leading to renal and cardiovascular injuries are not yet known. Besides, the greatest toxic effects appear to be induced by compounds that are difficult to remove by dialysis. Considering the close relationship between renal and cardiovascular functions, an understanding of the mechanisms involved in the production, clearance and overall impact of uremic toxins is extremely relevant for the understanding of pathologies of the cardiovascular system. Thus, the present study has as main focus to present an extensive review on the impact of uremic toxins in the cardiovascular system, bringing the state of the art on the subject as well as clinical implications related to patient’s therapy affected by chronic kidney disease, which represents high mortality of patients with cardiac comorbidities.
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影响因子：
3.7
作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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