Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension
Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension
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DOI：
10.1136/bjo.2006.094326
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发表时间：
2006-11-01
影响因子：
4.1
通讯作者：
Catoira, Y.
中科院分区：
文献类型：
--
作者：
Cantor, L. B.;Hoop, J.;Catoira, Y.
目的：评价比马前列素和曲伏前列素对青光眼合并高眼压患者的降眼压作用。方法：前瞻性、随机、随机、双盲、平行对照临床试验。在完成所有青光眼药物的洗脱后，患者(n=157)被随机分成两组，分别服用比马前列酮或曲伏前列素，疗程为6个月。随访时间分别为基线、1周、1、3和6个月。结果：基线、09：00、13：00、16：00h组间眼压差异无统计学意义(p>；=0.741)。6个月后，两种药物均能显著降低眼压(p
Aim: To evaluate the efficacies of bimatoprost and travoprost for lowering of intraocular pressure (IOP) for the treatment of glaucoma and ocular hypertension.Methods: Prospective, randomised, investigator-blinded, parallel-group clinical trial. After completing a washout of all glaucoma drugs, patients (n = 157) were randomised to bimatoprost or travoprost for 6 months. Visits were at baseline, 1 week, and 1, 3 and 6 months. IOP was measured at 09: 00 h at each visit and also at 13: 00 and 16: 00 h at baseline and at 3 and 6 months.Results: No significant between-group differences were observed in IOP at baseline, at 09: 00, 13: 00 or 16:00 h (p >= 0.741). After 6 months, both drugs significantly reduced IOP at every time point (p