Blood-based signatures in type 1 diabetes.
Blood-based signatures in type 1 diabetes.
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DOI：
10.1007/s00125-015-3843-x
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发表时间：
2016-03
期刊：
影响因子：
8.2
通讯作者：
Hessner MJ
中科院分区：
文献类型：
--
作者：
Cabrera SM;Chen YG;Hagopian WA;Hessner MJ
1型糖尿病是儿童期最常见的慢性疾病之一。它通过自身免疫破坏胰腺β细胞而发展，并导致终身依赖外源性胰岛素。1型糖尿病的发病机制涉及遗传和环境因素的复杂相互作用，历史上被归因于异常的适应性免疫;然而，越来越多的证据表明先天性炎症的作用。在过去的十年中，用于分析核酸和蛋白质信号的新方法已被应用于1型糖尿病。这些研究提供了对1型糖尿病发病机制的新认识，并有可能为开发新的生物标志物预测糖尿病发作和监测治疗干预提供信息。在这篇综述中，我们将集中在1型糖尿病的血液为基础的签名，特别注意直接转录分析全血和免疫细胞亚群，以及血浆/血清诱导的转录签名。还将关注蛋白质组学，microRNA检测和β细胞死亡的标志物。我们还将讨论在自身免疫性糖尿病自然史中涉及的遗传和环境因素的背景下，1型糖尿病的血液分析结果。
Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and has historically been attributed to aberrant adaptive immunity; however, there is increasing evidence for a role of innate inflammation. Over the past decade new methodologies for the analysis of nucleic acid and protein signals have been applied to type 1 diabetes. These studies are providing a new understanding of type 1 diabetes pathogenesis and have the potential to inform the development of new biomarkers for predicting diabetes onset and monitoring therapeutic interventions. In this review we will focus on blood-based signatures in type 1 diabetes, with special attention to both direct transcriptomic analyses of whole blood and immunocyte subsets, as well as plasma/serum-induced transcriptional signatures. Attention will also be given to proteomics, microRNA assays and markers of beta cell death. We will also discuss the results of blood-based profiling in type 1 diabetes within the context of the genetic and environmental factors implicated in the natural history of autoimmune diabetes.