Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles.
Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles.
复制标题
负载纳曲酮的可水解交联纳米颗粒的设计。
DOI：
10.1016/s0378-5173(02)00297-1
复制
发表时间：
2002
影响因子：
5.8
通讯作者：
Taylor,RobertE
中科院分区：
文献类型：
--
作者：
Yin,Wusheng;Akala,EmmanuelO;Taylor,RobertE
采用改进的方法合成了一种可水解交联剂N，O-二甲基丙烯酰羟胺（MANHOMA），并用1H-NMR、FTIR和熔点测定等方法对其结构进行了表征。以聚乙二醇1000单甲基醚单甲基丙烯酸酯（PEO MA）、甲基丙烯酸甲酯（MMA）和N，O-二甲基丙烯酰羟胺（MANHOMA）为原料，在0.4%聚乙烯醇水溶液中进行共聚反应，制备纳洛酮纳米粒。采用红外光谱、粒径测定和透射电镜对纳米粒子进行了表征。纳米颗粒的TEM显微照片显示由PEO-MA的聚乙二醇尾部形成的环包围的交联核。研究了纳米粒的载药效率和体外药物利用度。纳曲酮负载的可水解交联纳米颗粒能够维持纳曲酮的释放不同的时间段，这取决于单体进料组成。
A hydrolyzable crosslinker (N,O-dimethacryloylhydroxylamine (MANHOMA)) was synthesized by a modified method and was characterized using1H-NMR, FTIR, and melting point determination. Naltrexone-loaded nanoparticles were prepared by copolymerization of poly(ethylene glycol)1000 monomethyl ether mono methacrylate (PEO-MA), methyl methacrylate (MMA) and N,O-dimethacryloylhydroxylamine (MANHOMA) in 0.4% poly(vinyl alcohol) aqueous solution. The nanoparticles were characterized by FTIR, particle size determination and transmission electron microscope (TEM). The TEM photomicrographs of the nanoparticles show a crosslinked core surrounded by a ring formed by the polyethylene glycol tail of PEO-MA. The loading efficiency of the nanoparticles and in vitro drug availability from the nanoparticles were investigated. The naltrexone-loaded hydrolyzable crosslinked nanoparticles were able to sustain the release of naltrexone for different periods of time, depending on the monomer feed composition.