Changes in fibroglandular volume and water content of breast tissue during the menstrual cycle observed by MR imaging at 1.5 T
Changes in fibroglandular volume and water content of breast tissue during the menstrual cycle observed by MR imaging at 1.5 T
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DOI：
10.1002/jmri.1880050613
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发表时间：
1995-11-01
期刊：
影响因子：
--
通讯作者：
Plewes, DB
中科院分区：
文献类型：
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作者：
Graham, SJ;Stanchev, PL;Plewes, DB
磁共振成像在1.5 T被用来调查在月经周期中的乳腺实质的变化。7名受试者在至少一个月经周期内每周检查两次。三点狄克逊技术（TE = 19 msec，TR = 2000 msec）提供脂肪、水和静磁场（B-O）的图像，从中计算两个定量全乳房参数：平均相对体积含水量（WC）和平均体积纤维腺体分数（FV）。7例受试者中有4例显示（WC）和（FV）的明确周期变化与预期的组织学变化一致;（WC）和（FV）值在月经期间升高，在周期中期降低。四名受试者中每名受试者测量的最大偏差小于或等于10%（WC）和（FV）单位，这些变化可能不会显著影响未增强MR乳腺图像的临床解释。然而，乳房实质的定量测量应该认识到这些影响。
MR imaging at 1.5 T was used to investigate variations in breast parenchyma during the menstrual cycle. Seven subjects were examined twice weekly over at least one menstrual cycle. A three-point Dixon technique (TE = 19 msec, TR = 2000 msec) provided images of fat, water, and static magnetic field (B-O), from which two quantitative whole breast parameters were calculated: the mean relative volumetric water content, (WC), and the mean volumetric fibroglandular fraction, (FV). Four of seven subjects showed unequivocal cyclic variations in (WC) and (FV) consistent with expected histologic changes; (WC) and (FV) values were elevated during menses and reduced in mid-cycle. The maximum deviation measured for each of the four subjects was less than or equal to 10% in (WC) and (FV) units, These variations probably do not influence significantly the clinical interpretation of unenhanced MR breast images. Quantitative measurements of breast parenchyma, however, should recognize these effects.