Comparing phylogenetic codivergence between polyomaviruses and their hosts
Comparing phylogenetic codivergence between polyomaviruses and their hosts
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DOI：
10.1128/jvi.00056-06
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发表时间：
2006-06-01
影响因子：
5.4
通讯作者：
Crandall, Keith A.
中科院分区：
文献类型：
--
作者：
Perez-Losada, Marcos;Christensen, Ryan G.;Crandall, Keith A.
采用最大似然和贝叶斯方法分析了9种哺乳动物（67株）和2种禽类（5株）多瘤病毒的72个全基因组。我们的完全解析和良好支持（自举比例> 90%；后验概率= 1.0）树将鸟类多瘤病毒（禽类多瘤病毒和鹅出血性多瘤病毒）与哺乳动物多瘤病毒分离开来，这支持了将属划分为两个亚属的观点。这种分裂也与每一组不同的病毒生命策略相一致。类人猿（类人猿病毒40、类人猿制剂12 [Sa12]和嗜淋巴多瘤病毒）和啮齿动物（仓鼠多瘤病毒、小鼠多瘤病毒和小鼠嗜肺多瘤病毒[MPtV]）多瘤病毒没有形成单系群。利用我们对多瘤病毒进化关系的最佳假设和已建立的宿主系统发育，我们进行了共分化的共进化和解分析。结果显示，多瘤病毒科与鸟类和哺乳动物宿主共同进化，共发生了12次共分化（P < 0.01）。作为单个谱系，我们的分析显示了四个末端分支中宿主切换的证据，导致MPtV、牛多瘤病毒、Sa12和BK病毒，这表明多瘤病毒的进化史中存在垂直和水平转移的组合。
Seventy-two full genomes corresponding to nine mammalian (67 strains) and two avian (5 strains) polyomavirus species were analyzed using maximum likelihood and Bayesian methods of phylogenetic inference. Our fully resolved and well-supported (bootstrap proportions > 90%; posterior probabilities = 1.0) trees separate the bird polyomaviruses (avian polyomavirus and goose hemorrhagic polyomavirus) from the mammalian polyomaviruses, which supports the idea of spitting the genus into two subgenera. Such a split is also consistent with the different viral life strategies of each group. Simian (simian virus 40, simian agent 12 [Sa12], and lymphotropic polyomavirus) and rodent (hamster polyornavirus, mouse polyomavirus, and murine pneumotropic polyomavirus [MPtV]) polyomaviruses did not form monophyletic groups. Using our best hypothesis of polyomavirus evolutionary relationships and established host phylogenies, we performed a cophylogenetic reconciliation analysis of codivergence. Our analyses generated six optimal cophylogenetic scenarios of coevolution, including 12 codivergence events (P < 0.01), suggesting that Polyomaviridae coevolved with their avian and mammal hosts. As individual lineages, our analyses showed evidence of host switching in four terminal branches leading to MPtV, bovine polyornavirus, Sa12, and BK virus, suggesting a combination of vertical and horizontal transfer in the evolutionary history of the polyomaviruses.