Comparative analysis of mu-opioid receptor expression in immune and neuronal cells
Comparative analysis of mu-opioid receptor expression in immune and neuronal cells
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DOI：
10.1016/j.jneuroim.2007.05.007
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Kraus, Juergen
中科院分区：
文献类型：
--
作者：
Boerner, Christine;Stumm, Ralf;Kraus, Juergen
吗啡通过阿片受体调节神经元和免疫细胞功能。在原代和Jurkat T细胞和Raji B细胞中，只有在IL-4或tnf - α刺激细胞后才能检测到p -阿片受体转录物。此外，免疫细胞中诱导的it -阿片受体mRNA的量比原代皮质和SH SY5Y神经元细胞少15 ~ 200倍。然而，免疫细胞中的p-阿片受体mRNA被加工成功能性受体，如吗啡介导的丝裂原活化蛋白激酶磷酸化、吗啡介导的IL-4 mRNA上调和Jurkat细胞中腺苷酸环化酶的偶联。(c) 2007 Elsevier b.v.版权所有
Morphine modulates neuronal and immune cell functions via [mu-opioid receptors. In primary and Jurkat T cells, and Raji B cells P-opioid receptor transcripts were detected only after stimulation of the cells with IL-4 or TNF-alpha. Moreover, the amount of the induced It-opioid receptor mRNA in the immune cells was 15 to 200 times less than those in primary cortical and SH SY5Y neuronal cells. Nevertheless, P-opioid receptor mRNA in immune cells is processed to functional receptors, as demonstrated by morphine-mediated phosphorylation of mitogen activated protein kinase, morphine-mediated up-regulation of IL-4 mRNA and coupling to adenylyl cyclase in Jurkat cells. (c) 2007 Elsevier B.V All rights reserved.