Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia
Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia
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DOI：
10.1089/acm.2007.0793
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发表时间：
2008-06-01
影响因子：
2.6
通讯作者：
Son, Chang Gue
中科院分区：
文献类型：
--
作者：
Cho, Jung Hyo;Chung, Weon Kuu;Son, Chang Gue
目的：放射治疗引起的口干症严重降低了头颈癌患者的生活质量。本研究旨在探讨手法针刺对癌症放射性口干症患者主客观症状变化的影响。材料与方法：将12例放射性口干症患者随机分为2组(真针刺组和假针刺组)。针灸治疗采用单盲法，每周两次，共6周。治疗前、治疗后3周、6周(针灸治疗后3周、6周)分别测量全唾液流率(刺激性和非刺激性)和主观症状问卷评分进行疗效评价。结果：两组患者的全唾液流率均略有增加，但差异无统计学意义。然而，真正的针刺显著增加非刺激性唾液流率，并改善口干症问卷的口干评分，2.33分比对照组的0.33分。结论：我们的结果显示，我们的结果显著改善了与生活质量密切相关的头颈部肿瘤放疗患者的口干症主观感觉。
Purpose: Radiotherapy-induced xerostomia seriously reduces the quality of life (QOL) for patients with head and neck cancer. This study aimed to investigate the effects of manual acupuncture on objective and subjective assessment of symptom changes in patients with cancer who have with radiation-induced xerostomia.Materials and methods: Twelve (12) patients with radiation-induced xerostomia were randomized into 2 groups (real or sham acupuncture). Acupuncture was conducted twice weekly for 6 weeks in a single-blind setting. The effect was evaluated by measuring whole salivary flow rates (stimulated and unstimulated) and questionnairebased assessment of subjective symptoms pre-and post-treatment (3 and 6 weeks after acupuncture treatment).Results: Both groups showed a slight increase in whole salivary flow rates, with no significant difference between them. However, real acupuncture markedly increased unstimulated salivary flow rates, and improved the score for dry mouth according to the xerostomia questionnaire, by 2.33 points versus 0.33 in the controls.Conclusions: Our results showed the significantly meaningful amelioration of the subjective sensation of xerostomia closely associated with QOL in patients with head and neck cancer treated with irradiation.