The role of MRI in the assessment of polymyositis and dermatomyrositis
The role of MRI in the assessment of polymyositis and dermatomyrositis
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DOI：
10.1093/rheumatology/kem088
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发表时间：
2007-07-01
期刊：
影响因子：
5.5
通讯作者：
Vencovsky, J.
中科院分区：
文献类型：
--
作者：
Studynkova, J. Tomasova;Charvat, F.;Vencovsky, J.
目标.特发性炎性肌病（IIM）中的急性炎症引起水肿，可通过磁共振成像（MRI）观察到。IN的炎性浸润被认为是常见的局灶性分布。本研究的目的是更好地评估大腿肌肉MR图像与临床和组织学参数的关系。MRI-短tau反转恢复（STIR）技术用于区分受累和非受累肌肉。使用计算机断层扫描（CT）控制的靶向穿刺活检进行采样。采用10 cm视觉模拟评分法评价肌肉水肿的强度、范围及MRI总体评价。炎症浸润的强度采用5分评分系统进行评估。治疗结束后进行第二次MRI检查和肌肉活检。对29例多发性肌炎（PM）和皮肌炎（DM）患者进行了MR扫描、肌肉活检和临床检查。从17例病例中获得配对的MRI受影响和MRI未受影响的活检样本。在6例病例中，活检可用于治疗前后的比较。在最初的检查中，MRI上水肿的强度与临床状态相关。10例患者的MRI结果的平均强度显著降低，其中MRI在治疗后也可用。PM/DM患者MRI受累肌肉的平均炎症浸润强度为2.5 ± 0.7，MRI未受累肌肉的平均炎症浸润强度为1.7 ± 0.6（P
Objectives. Acute inflammation in idiopathic inflammatory myopathies (IIM) causes oedema that can be visualized by magnetic resonance imaging (MRI). The inflammatory infiltrate in IN is thought to be frequently in a focal distribution. The aim of this study is to better evaluate the relationship of MR image of thigh muscles to clinical and histological parameters in patients with IIM.Methods. MRI-short tau inversion recovery (STIR) technique was used to distinguish between affected and non-affected muscles. Computer tomography (CT)-controlled targeted needle biopsy was used for sampling. The intensity of muscle oedema, its extent and total assessment on MRI were evaluated with 10 cm visual analogue scale. The intensity of inflammatory infiltrate was assessed using 5-point grading system. The second MRI and muscle biopsy were performed after the time interval of treatment.Results. MR scans, muscle biopsy and clinical examination were performed in 29 patients with polymyositis (PM) and dermatomyositis (DM). Paired MRI-affected and MRI-non-affected biopsy samples were obtained from 17 cases. In six cases, the biopsy was available for comparison before and after period of treatment. At the initial examination, it was the intensity of oedema on MRI that was associated with clinical status. Mean intensity of MRI findings significantly decreased in 10 patients where the MRI was available also after treatment. The mean intensity of inflammatory infiltrate in PM/DM patients was 2.5 +/- 0.7 for MRI-affected and 1.7 +/- 0.6 for MRI-non-affected muscles (P