Regulatory T cells
Regulatory T cells
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DOI：
10.1038/sj.jid.5700004
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发表时间：
2006-01-01
影响因子：
6.5
通讯作者：
Schwarz, Thomas
中科院分区：
文献类型：
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作者：
Beissert, Stefan;Schwarz, Agatha;Schwarz, Thomas
免疫自我耐受主要取决于免疫反应的诱导，但也取决于免疫反应的下调。尽管多年来被忽视和忽略，抑制性 T 细胞（现已更名为调节性 T 细胞 (Treg)）在免疫反应的负调节中发挥着重要作用。已经描述了 Tregs 的几个子集。天然存在的 CD4(+) CD25(+) Tregs 在预防自身免疫性疾病中发挥着重要作用。 1 型 Treg 是另一种可诱导的 Treg 亚型，主要通过释放 IL-10 发挥其抑制活性。关于这些细胞的表型和作用模式的详细了解将显着增加我们对自身免疫性疾病发病机制的理解，也将有助于确定新的治疗策略。
Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described. Naturally occurring CD4(+) CD25(+) Tregs are important in the prevention of autoimmune diseases. Type 1 Tregs, another subtype of Treg that is inducible, exert their suppressive activity primarily via the release of IL-10. Detailed knowledge about the phenotype and mode of action of these cells will significantly increase our understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.