The interaction of triethyltin with components of animal tissues.
The interaction of triethyltin with components of animal tissues.
复制标题
三乙基锡与动物组织成分的相互作用。
作者：
M. Rose;W. Aldridge
1.氯化三乙基[（113）Sn]锡在大鼠、豚鼠和仓鼠体内的分布并不均匀，最高浓度出现在所有三个物种的大鼠血液和肝脏中。2.大鼠肝、脑和肾的亚细胞分级显示，三乙基锡与所有组分都有不同程度的结合。在大鼠和豚鼠的肝脏中，上清液部分含有最大量和最高比浓度;该三乙基锡与不可扩散组分结合。3.大鼠血红蛋白负责结合大鼠血液中的三乙基锡（2摩尔三乙基锡/摩尔血红蛋白）。其他物种的血红蛋白对三乙基锡的亲和力要低得多。4.许多其他蛋白质不结合三乙基锡。
1. The distribution of triethyl[(113)Sn]tin chloride in the rat, guinea pig and hamster is not uniform, the highest concentrations being in rat blood and the liver of all three species. 2. Subcellular fractionation of rat liver, brain and kidney shows that triethyltin binds to all fractions to different extents. In the liver of the rat and guinea pig the supernatant fraction contains the largest amount and the highest specific concentration; this triethyltin is bound to a non-diffusible component. 3. Rat haemoglobin is responsible for the binding of triethyltin in rat blood (2 moles of triethyltin/mole of haemoglobin). Haemoglobins from other species have much less affinity for triethyltin. 4. A variety of other proteins do not bind triethyltin.