Cardiac sarcoidosis
Cardiac sarcoidosis
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DOI：
10.1136/hrt.2005.080481
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发表时间：
2006-02-01
期刊：
影响因子：
5.7
通讯作者：
Williams, BR
中科院分区：
文献类型：
--
作者：
Doughan, AR;Williams, BR
人们越来越认识到结节病患者的心脏受累，并且与不良预后相关。尽管环境和遗传因素与其发病机制有关，但心脏结节病的病因仍不清楚。临床表现包括晚期心脏传导阻滞、心律失常和充血性心力衰竭。迄今为止，心脏结节病的临床诊断极其困难，因为其临床表现非特异性，且诊断方式的敏感性和特异性有限。心脏结节病的最佳治疗方法尚未明确。尽管皮质类固醇仍然是主要的治疗方法，但几乎没有证据表明治疗的最佳起始时间、剂量或持续时间。本文将为读者介绍心脏结节病的临床表现和病理生理学的最新信息，特别关注最新的诊断和治疗方式。
Cardiac involvement in patients with sarcoidosis is being increasingly recognised and is associated with poor prognosis. Although environmental and genetic factors have been implicated in its pathogenesis, the aetiology of cardiac sarcoidosis remains obscure. Clinical manifestations include advanced heart block, arrhythmias, and congestive heart failure. To date, cardiac sarcoidosis has been extremely difficult to diagnose clinically because the clinical manifestations are non-specific, and the sensitivity and specificity of diagnostic modalities are limited. The optimal management of cardiac sarcoidosis has not been well defined. Although corticosteroids remain the mainstay of treatment, there is little evidence for the optimal initiation, dosage, or duration of therapy. This article will update the reader on the clinical manifestations and pathophysiology of cardiac sarcoidosis, with a special focus on recent diagnostic and therapeutic modalities.