EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewal.
EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewal.
复制标题
DOI：
10.1080/23262133.2016.1250034
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Martinez-Balbas, Marian A
中科院分区：
文献类型：
--
作者：
Akizu, Naiara;Martinez-Balbas, Marian A
在神经发育的早期阶段，神经上皮细胞以与细胞周期协调的方式沿顶基轴转移其细胞核。细胞周期进程和神经上皮极性如何协调尚不清楚。有人提出，为了协调这些过程，发育线索、表观遗传机制和细胞周期调节必须联系起来。我们最近发现，一个主要的表观遗传因子EZH2对协调这些事件至关重要。EZH2在鸡脊髓中直接抑制细胞周期调节因子p21WAF1/CIP。通过这样做，EZH2控制神经祖细胞更新和微调Rho信号通路，这是维持神经上皮结构所必需的。我们的发现指出了EZH2在发育过程中的新作用，这可能对癌症等其他领域有潜在的影响。
During early stages of neural development, neuroepithelial cells translocate their nuclei along the apicobasal axis in a harmonized manner with the cell cycle. How cell cycle progression and neuroepithelium polarity are coordinated remains unclear. It has been proposed that developmental cues, epigenetic mechanisms and cell cycle regulators must be linked in order to orchestrate these processes. We have recently discovered that a master epigenetic factor, EZH2 is essential to coordinate these events. EZH2 directly represses the cell cycle regulator p21WAF1/CIP in the chicken spinal cord. By doing so, EZH2 controls neural progenitor cell renewal and fine-tunes Rho signaling pathway, which is essential to maintain neuroepithelial structure. Our findings point to a new role of EZH2 during development that could have potential implication in other areas as cancer.