Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.
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DOI：
10.1084/jem.153.6.1445
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发表时间：
1981-06-01
期刊：
影响因子：
--
通讯作者：
Dorf ME
中科院分区：
文献类型：
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作者：
Sherr DH;Dorf ME
体外研究了静脉注射4-羟基-3-硝基苯基乙酰（NP）修饰的同源脾细胞诱导T抑制细胞影响正在进行的B细胞反应的能力。结果表明，在体外培养的最后24 h，抗原诱导抑制细胞可选择性抑制NPb独特型阳性B细胞的表达。这种B细胞反应的效应期抑制是抗原特异性的，由Lyt 1-， Lyt 2+，独特型结合的T细胞群介导，其抑制功能受到与Igh位点相关的基因的限制。
The ability of T suppressor cells, induced by the intravenous injection of 4-hydroxy-3-nitrophenyl acetyl (NP)-modified syngeneic spleen cells, to affect an ongoing B cell response was studied in vitro. It was found that the expression of NPb idiotype-positive B cells could be selectively inhibited by the addition of antigen-induced suppressor cells in the last 24 h of the in vitro culture. This effector-phase suppression of B cell responses was antigen specific and mediated by an Lyt 1-, Lyt 2+, idiotype-binding, T cell population whose suppressive function was restricted by genes linked to the Igh locus.