Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells
Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells
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DOI：
10.1080/095530097143725
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发表时间：
1997-06-01
影响因子：
2.6
通讯作者：
Joiner, MC
中科院分区：
文献类型：
--
作者：
Marples, B;Lambin, P;Joiner, MC
这篇手稿回顾了英国格雷实验室和加拿大不列颠哥伦比亚省癌症研究中心使用DMIPS细胞分析仪进行的低剂量生存研究。它描述了在单次剂量低于0.3GyX射线后检测到的低剂量超放射敏感性(HRS)，以及随后随着剂量增加到1Gy时出现的辐射抵抗反应(IRR)的增加。总结了对V79细胞、正常人和人类肿瘤细胞系以及DNA修复缺陷突变细胞系的研究。这些数据是根据这样一种假设来考虑的，即超辐射敏感性和增强的辐射抗性反映了一种可能由DNA损伤触发的诱导保护机制的存在。
This manuscript reviews the low-dose survival work using the DMIPS cell analyser that has been carried out at the Gray Laboratory in the U.K. and the British Columbia Cancer Research Centre in Canada. It describes low dose hyper-radiosensitivity (HRS) detected after single doses of X-rays less than similar to 0.3 Gy and the subsequent increased radioresistant response (IRR) seen as the dose increases up to 1 Gy. Work is summarized from studies in V79 cells, normal human and human tumour cell lines and mutant cell lines deficient in DNA repair. The data are considered in light of the hypothesis that hyper-radiosensitivity and increased radioresistance reflect the existence of an inducible protective mechanism, possibly triggered by DNA damage.