GABA-A AND GABA-B RECEPTOR-SITE DISTRIBUTION IN THE RAT CENTRAL-NERVOUS-SYSTEM
GABA-A AND GABA-B RECEPTOR-SITE DISTRIBUTION IN THE RAT CENTRAL-NERVOUS-SYSTEM
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DOI：
10.1016/0306-4522(87)90098-4
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发表时间：
1987-02-01
期刊：
影响因子：
3.3
通讯作者：
PRICE, GW
中科院分区：
文献类型：
--
作者：
BOWERY, NG;HUDSON, AL;PRICE, GW
用放射自显影方法测定了γ-氨基丁酸(GABAA和GABAB)受体亚型在大鼠脑内的定量分布。虽然这两个受体结合位点的浓度在某些脑区相似，但GABAA位点的数量通常多于GABAB位点。在额叶皮质、小脑颗粒细胞层、嗅球和丘脑内侧膝状体中GABAA含量最高。GABAB位点在小脑、脚间核、额叶皮质、嗅前核和丘脑核的分子层密度最高。此外，苍白球、颞叶皮质、丘脑外侧后部、上丘、桥核、中缝大核、三叉神经脊束和胶状质等部位的GABAB含量明显高于GABAA部位。这种异质性的生理和药理意义尚未确定。
An autoradiographic procedure has been used to determine the quantitative distributions of .gamma.-aminobutyric acid (GABAA and GABAB) receptor subtypes in rat brain. Although the concentrations of both receptor binding sites were similar in some brain regions GABAA sites generally outnumbered GABAB sites. The highest concentration of GABAA sites were detected in the frontal cortex, the granule cell layer of the cerebellum, the olfactory bulb and the thalamic medial geniculate. The highest concentration of GABAB sites occurred in the molecular layer of the cerebellum, the interpeduncular nucleus, frontal cortex, anterior olfactory nucleus and thalamic nuclei. In addition the globus pallidus, temporal cortex, lateral posterior thalamus, superior colliculus, pontine nucleus, raphe magnus, spinal trigeminal tract and substantia gelatinosa contained significantly more GABAB sites than GABAA sites. The physiological and pharmacological significance of this heterogeneity has yet to be determined.