A new compound from the fruit of Amorpha fruticosa and activity against acetaminophen-induced hepatotoxicity
A new compound from the fruit of Amorpha fruticosa and activity against acetaminophen-induced hepatotoxicity
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DOI：
10.1016/j.cclet.2009.03.039
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发表时间：
2009-08-01
影响因子：
9.1
通讯作者：
Kang, Ting Guo
中科院分区：
文献类型：
--
作者：
Diao, Yun Peng;Li, Kun;Kang, Ting Guo
从药用植物紫穗槐（Amorphafruticosa）中分离得到一个新化合物。经紫外光谱、红外光谱、核磁共振氢谱和二维核磁共振氢谱鉴定为苯并吡喃-12-酮，1，4，10，11-四氢-6 '-[8'-（羟甲基）乙烯基]-2，3-二甲氧基-8 '-O-β-D-吡喃葡萄糖基-O-α-D-阿拉伯糖苷。并对该化合物的抗醋氨酚肝毒性活性进行了研究，发现该化合物对醋氨酚（AAP）肝毒性有明显的保护作用。(C)2009年《亭国康》。Elsevier B. V.代表中国化学会出版。All rights reserved.
A new isoflavone was obstained from the medicinal herb Amorpha fruticosa. It was elucidated asbenzopyran-12-one,1,4,10,11-tetrahydro-6'-[8'-(hydroxymethyl)ethenyl]-2,3-dimethoxy-8'-O-beta-D-glucopyranosyl-O-alpha-D-arabinoside by spectroscopic methods including UV, IR, 1D NMR and 2D NMR techniques. And the activity against acetaminophen-induced hepatotoxicity of this compound was also studied, and found this compound can protect liver obviously from hepatotoxicity induced by acetaminophen (AAP). (C) 2009 Ting Guo Kang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.